In "What Matters Most — Aging, Technology and Artificial Intelligence," Johns Hopkins geriatricians Jessica Colburn and David Hurwitz share their views on how technology and artificial intelligence could benefit older adults. They discuss what challenges related to health care technology might address, considerations in the design and development of technology that are intended to help older adults and facilitators, and barriers to older adults' adoption of new technologies. Key takeaways included the potential of AI to enhance diagnostic capabilities, the importance of accessible and user-centered technology for older adults, and the need for support systems to help older adults adapt to new tools.